I use Photoshop most of the time and Manga Studio 5 when I’m feeling especially adventurous. Each of those programs has their advantages and disadvantages that I won’t really get into because it really all comes down to preference.
It’s easy to think that there’s going to be a program or a tablet or a pen or some kind of art supply that will change everything, but the reality is that all of that stuff just acts as an extension of what you’re already capable of.
So I guess my advice would be this: Just get comfortable drawing before getting too concerned with whether or not it’s digital. The rest will come naturally.